Evolution of biochip technology: A review from lab-on-a-chip to organ-on-a-chip

N Azizipour, R Avazpour, DH Rosenzweig, M Sawan… - Micromachines, 2020 - mdpi.com
Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel
biomedical application for microfluidic based devices has emerged in recent years and …

Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies

S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening

H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Design and fabrication of drug‐delivery systems toward adjustable release profiles for personalized treatment

A Geraili, M **ng, K Mequanint - View, 2021 - Wiley Online Library
Advanced polymeric controlled delivery systems are designed to effectively treat chronic
diseases by adjusting the temporal profile of drug release. Most conventional controlled …

Drug toxicity evaluation based on organ-on-a-chip technology: a review

Y Cong, X Han, Y Wang, Z Chen, Y Lu, T Liu, Z Wu… - Micromachines, 2020 - mdpi.com
Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising
area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a …

A novel organ-chip system emulates three-dimensional architecture of the human epithelia and the mechanical forces acting on it

A Varone, JK Nguyen, L Leng, R Barrile, J Sliz… - Biomaterials, 2021 - Elsevier
Successful translation of in vivo experimental data to human patients is an unmet need and
a bottleneck in the development of effective therapeutics. Organ-on-Chip technology aims to …

Advancing Intelligent Organ‐on‐a‐Chip Systems with Comprehensive In Situ Bioanalysis

X Li, H Zhu, B Gu, C Yao, Y Gu, W Xu… - Advanced …, 2024 - Wiley Online Library
In vitro models are essential to a broad range of biomedical research, such as pathological
studies, drug development, and personalized medicine. As a potentially transformative …

Recent advances in microfluidics for drug screening

J Sun, AR Warden, X Ding - Biomicrofluidics, 2019 - pubs.aip.org
With ever increasing drug resistance and emergence of new diseases, demand for new drug
development is at an unprecedented urgency. This fact has led to extensive recent efforts to …

Microfluidic-Based Oxygen (O2) Sensors for On-Chip Monitoring of Cell, Tissue and Organ Metabolism

M Azimzadeh, P Khashayar, M Amereh, N Tasnim… - Biosensors, 2021 - mdpi.com
Oxygen (O2) quantification is essential for assessing cell metabolism, and its consumption in
cell culture is an important indicator of cell viability. Recent advances in microfluidics have …

Gut-on-chip for ecological and causal human gut microbiome research

S Moossavi, MC Arrieta, A Sanati-Nezhad… - Trends in …, 2022 - cell.com
There is a growing interest to understand if and how the gut microbiome is causally linked to
the pathogenesis and/or progression of diseases. While in vitro cell line models are …