In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Summary PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a
phosphoswitch that controls PER stability and repressive activity in the molecular clock …

The prevalence of intrinsically disordered protein regions, particularly in eukaryotic proteins,
and their clear functional advantages for signaling and gene regulation have created an …

Tumor suppressor activation or reactivation has long been a sought-after, yet elusive,
therapeutic strategy for human cancer. Phosphatase and tensin homolog (PTEN) is one of …

The tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN) is a
tightly regulated enzyme responsible for dephosphorylating the progrowth lipid messenger …

Time-resolved experiments demand high resolution both in spectral dimensions and in time
of the studied kinetic process. The latter requirement traditionally prohibits applications of …

The tumor suppressor PIP3 phosphatase PTEN is phosphorylated on four clustered Ser/Thr
on its C-terminal tail (aa 380–385) and these phosphorylations are proposed to induce a …

The p53 homolog TAp63α is the transcriptional key regulator of genome integrity in oocytes.
After DNA damage, TAp63α is activated by multistep phosphorylation involving multiple …