Standing watch over the proteome, molecular chaperones are an ancient and evolutionarily
conserved class of proteins that guide the normal folding, intracellular disposition and …

Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible
isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different …

Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …

The 90 kDa heat shock proteins (Hsp90), which are integrally involved in cell signaling,
proliferation, and survival, are ubiquitously expressed in cells. Many proteins in tumor cells …

Molecular chaperones or so-called heat shock proteins serve as central integrators of
protein homeostasis within cells. In performing this function, they guide the folding …

The 90-kDa heat-shock protein (Hsp90) is a molecular chaperone responsible for the
stability and function of a wide variety of client proteins that are critical for cell growth and …

Permeability edema is a life-threatening complication accompanying acute lung injury (ALI),
severe pneumonia and the acute respiratory distress syndrome (ARDS), which can be …

The molecular chaperone heat shock protein 90 (HSP90) has emerged as an exciting
molecular target for cancer therapy. It operates as part of a multichaperone complex and is …

The molecular chaperone Hsp90 has emerged as an important target in cancer treatment
because of its roles in maintaining transformation and regulating the function of proteins …

The C-terminal domain of Hsp90 displays independent chaperone activity, mediates
dimerization, and contains the MEEVD motif essential for interaction with tetratricopeptide …