Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

In this review those fluorinated compounds which have found a role as anti-cancer agents
are summarized. The emphasis is to highlight the important drugs but also to highlight the …

The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …

Fluorinated small molecules are prevalent across the functional small-molecule spectrum,
but the scarcity of naturally occurring sources creates an opportunity for creative endeavour …

Despite a long and distinguished history focused on the isolation and structural elucidation
of secondary metabolites from all classes of organisms, organic chemists have only securely …

Carbohydrate diversity is foundational in the molecular literacy that regulates cellular
function and communication. Consequently, delineating and leveraging this structure …

This present report is devoted to the recent advances, in these last 10 years, in fluorinated
analogues of natural products developed as pharmaceuticals, marketed, registered or in …

Halogenated molecules are widely distributed in the biosphere. A variety of halogenated
aromatic and aliphatic compounds are man-made and can be harmful to the environment …

Organofluorine compounds are widely used in many different applications, ranging from
pharmaceuticals and agrochemicals to advanced materials and polymers. It has been …

Fluorinases, the only enzymes known to catalyze the transfer of fluorine to an organic
molecule, are essential catalysts for the biological synthesis of valuable organofluorines …