Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

The core axoneme structure of both the motile cilium and sperm tail has the same
ultrastructural 9+ 2 microtubular arrangement. Thus, it can be expected that genetic defects …

Severe asthenozoospermia is a common cause of male infertility. Recent studies have
revealed that SPEF2 mutations lead to multiple morphological abnormalities of the sperm …

Background Male infertility due to multiple morphological abnormalities of the sperm flagella
(MMAF) is a genetically heterogeneous disorder. Previous studies revealed several MMAF …

Ciliary beating requires the coordinated activity of numerous axonemal complexes. The
protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs …

Our understanding of motile cilia and their role in disease has increased tremendously over
the last two decades, with critical information and insight coming from the analysis of mouse …

Personalized medicine is focused on research disciplines which contribute to the
individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute …

Male patients with multiple morphological abnormalities of the sperm flagella (MMAF) are
infertile and exhibit absent, short, coiled, bent and/or irregular sperm flagella. Mutations in …

Motile cilia and homologous organelles, the flagella, are an early evolutionarily invention,
enabling primitive eukaryotic cells to survive and reproduce. In animals, cilia have …

Objective: To define the cross-reactivity potential and the consequent autoimmunity intrinsic
to viral versus human peptide sharing. Methods: Using human papillomavirus (HPV) …