Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine
Y Duo, L Han, Y Yang, Z Wang, L Wang… - Chemical …, 2024 - ACS Publications
Biopsy, including tissue and liquid biopsy, offers comprehensive and real-time physiological
and pathological information for disease detection, diagnosis, and monitoring. Fluorescent …
and pathological information for disease detection, diagnosis, and monitoring. Fluorescent …
Genetics of chronic respiratory disease
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
Large-scale plasma proteomics comparisons through genetics and disease associations
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
Proteomic signatures improve risk prediction for common and rare diseases
For many diseases there are delays in diagnosis due to a lack of objective biomarkers for
disease onset. Here, in 41,931 individuals from the United Kingdom Biobank Pharma …
disease onset. Here, in 41,931 individuals from the United Kingdom Biobank Pharma …
Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank
The emergence of biobank-level datasets offers new opportunities to discover novel
biomarkers and develop predictive algorithms for human disease. Here, we present an …
biomarkers and develop predictive algorithms for human disease. Here, we present an …
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …
Blood protein assessment of leading incident diseases and mortality in the UK Biobank
The circulating proteome offers insights into the biological pathways that underlie disease.
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …
Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age …
Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations
Circulating plasma proteins play key roles in human health and can potentially be used to
measure biological age, allowing risk prediction for age-related diseases, multimorbidity and …
measure biological age, allowing risk prediction for age-related diseases, multimorbidity and …
Rare variant associations with plasma protein levels in the UK Biobank
Integrating human genomics and proteomics can help elucidate disease mechanisms,
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …
Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura
Migraine is a complex neurovascular disease with a range of severity and symptoms, yet
mostly studied as one phenotype in genome-wide association studies (GWAS). Here we …
mostly studied as one phenotype in genome-wide association studies (GWAS). Here we …