The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Abstract In 2005, the International Union of Basic and Clinical Pharmacology Committee on
Receptor Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of …

Pancreatic cancer (PC) is one of the deadliest cancers and remains a major challenge due
to its invasive and metastatic nature. Increased levels of CCR5 and CCL5 have established …

Rationale: 20-Hydroxyeicosatetraenoic acid (20-HETE), one of the principle cytochrome
P450 eicosanoids, is a potent vasoactive lipid whose vascular effects include stimulation of …

G protein-coupled receptors (GPCRs) are usually highlighted as being both the largest
family of membrane proteins and the most productive source of drug targets. However, most …

Background The superfamily of G protein-coupled receptors (GPCRs) is one of the largest
within most mammals. GPCRs are important targets for pharmaceuticals and the rat is one of …

HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …

Tamoxifen is the most frequently used anti-hormonal drug for treatment of women with
hormone-dependent breast cancer. The aim of this study is to investigate the mechanism of …