Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …
sequence diversity and binding versatility have made Abs the primary class of …
Tracing antibody repertoire evolution by systems phylogeny
Antibody evolution studies have been traditionally limited to either tracing a single clonal
lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk …
lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk …
An engineered biomimetic MPER peptide vaccine induces weakly HIV neutralizing antibodies in mice
S Shao, WC Huang, C Lin, MD Hicar… - Annals of biomedical …, 2020 - Springer
A vaccine that induces broadly neutralizing antibodies (bnAbs) against the human
immunodeficiency virus (HIV) would be instrumental in controlling the disease. The …
immunodeficiency virus (HIV) would be instrumental in controlling the disease. The …
Induction of potent and durable neutralizing antibodies against SARS-CoV-2 using a receptor binding domain-based immunogen
A novel betacoronavirus (SARS-CoV-2) that causes severe pneumonia emerged through
zoonosis in late 2019. The disease, referred to as COVID-19, has an alarming mortality rate …
zoonosis in late 2019. The disease, referred to as COVID-19, has an alarming mortality rate …
Automated analysis of immunosequencing datasets reveals novel immunoglobulin D genes across diverse species
Immunoglobulin genes are formed through V (D) J recombination, which joins the variable
(V), diversity (D), and joining (J) germline genes. Since variations in germline genes have …
(V), diversity (D), and joining (J) germline genes. Since variations in germline genes have …
Brief introduction of current technologies in isolation of broadly neutralizing HIV-1 antibodies
HIV/AIDS has become a worldwide pandemic. Before an effective HIV-1 vaccine eliciting
broadly neutralizing monoclonal antibodies (bnmAbs) is fully developed, passive …
broadly neutralizing monoclonal antibodies (bnmAbs) is fully developed, passive …
Serum Proteomics Expands on Identifying More High-Affinity Antibodies in Immunized Rabbits Than Deep B-Cell Repertoire Sequencing Alone
Rabbits are a model for immunology studies, and monoclonal antibodies developed from
rabbits have been sought after to empower immunoassays in a variety of applications. High …
rabbits have been sought after to empower immunoassays in a variety of applications. High …
Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice
M Kuchař, P Kosztyu, V Daniel Lišková, J Černý… - Virulence, 2021 - Taylor & Francis
One of the proposed strategies for the development of a more efficient HIV-1 vaccine is
based on the identification of proteins binding to a paratope of chosen broadly neutralizing …
based on the identification of proteins binding to a paratope of chosen broadly neutralizing …
Commonly elicited antibodies against the base of the HIV-1 Env trimer guide the population-level evolution of a structure-regulating region in gp41
The antibody response against the HIV-1 envelope glycoproteins (Envs) guides evolution of
this protein within each host. Whether antibodies with similar target specificities are elicited …
this protein within each host. Whether antibodies with similar target specificities are elicited …
IgEvolution: clonal analysis of antibody repertoires
Constructing antibody repertoires is an important error-correcting step in analyzing
immunosequencing datasets that is important for reconstructing evolutionary (clonal) …
immunosequencing datasets that is important for reconstructing evolutionary (clonal) …