Cancer remains a serious burden in society and while the pace in the development of novel
and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor …

Gastrointestinal (GI) cancers, including colorectal, gastric, esophageal, pancreatic, and liver,
are associated with high mortality and morbidity rates worldwide. One of the underlying …

Cell and organ metabolism is organized through various signaling mechanisms, including
redox, Ca 2+, kinase and electrochemical pathways. Redox signaling operates at multiple …

Extracellular vesicles (EVs) are generated in all cells. Systemic administration of allogenic
EVs derived from epithelial and mesenchymal cells has been shown to be safe, despite …

Both progression from the early pathogenic events to clinically manifest cardiovascular
diseases (CVD) and cancer impact the integrity of the vascular system. Pathological …

VEGFR2 (Vascular endothelial growth factor receptor 2) is a central regulator of placental
angiogenesis. The study of the VEGFR2 proteome of chorionic villi at term revealed its …

Adequate vascularization is a critical determinant for the successful construction and clinical
implementation of complex organotypic tissue models. Currently, low cell and vessel density …

Objectives To investigate the clinical value of pre-treatment quantitative contrast-enhanced
ultrasound (CEUS) in assessing the response of colorectal liver metastases (CRLM) to …

Cell and organ metabolism is organized through various signaling mechanisms, including
redox, Ca2+, kinase and electrochemical pathways. Redox signaling operates at multiple …

Among multiple pathways of intercellular communication operative in multicellular
organisms, the trafficking of extracellular vesicles (EVs) and particles (EP) represents a …