Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review

T Teka, L Zhang, X Ge, Y Li, L Han, X Yan - Phytochemistry, 2022 - Elsevier
Stilbenes are some of the important phenolic compounds originating from plant families like
Vitaceae, Leguminaceae, Gnetaceae, and Dipterocarpaceae. Structurally, they have a C6 …

Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer

L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …

Natural products as potential lead compounds to develop new antiviral drugs over the past decade

JH Zhao, YW Wang, J Yang, ZJ Tong, JZ Wu… - European Journal of …, 2023 - Elsevier
Virus infection has been one of the main causes of human death since the ancient times.
Even though more and more antiviral drugs have been approved in clinic, long-term use can …

Navigating the chemical space and chemical multiverse of a unified Latin American natural product database: LANaPDB

A Gómez-García, DAA Jiménez, WJ Zamora… - Pharmaceuticals, 2023 - mdpi.com
The number of databases of natural products (NPs) has increased substantially. Latin
America is extraordinarily rich in biodiversity, enabling the identification of novel NPs, which …

[HTML][HTML] Schaftoside inhibits 3CLpro and PLpro of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19

Y Yi, M Zhang, H Xue, R Yu, YO Bao, Y Kuang… - … Pharmaceutica Sinica B, 2022 - Elsevier
It is an urgent demand worldwide to control the coronavirus disease 2019 (COVID-19)
pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

ChatGPT in drug discovery

G Sharma, A Thakur - 2023 - chemrxiv.org
ChatGPT is a language model developed by OpenAI. It is a machine learning model that has
been trained on a large dataset of human language, allowing it to generate human-like text …

Luteolin inhibits spike protein of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) binding to angiotensin‐converting enzyme 2

J Zhu, H Yan, M Shi, M Zhang, J Lu… - Phytotherapy …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), a respiratory illness that poses a serious threat to global public …

Stand up to stand out: natural dietary polyphenols curcumin, resveratrol, and gossypol as potential therapeutic candidates against severe acute respiratory syndrome …

Z Wang, X Song, W Xu, S Lei, H Zhang, L Yang - Nutrients, 2023 - mdpi.com
The COVID-19 pandemic has stimulated collaborative drug discovery efforts in academia
and the industry with the aim of develo** therapies and vaccines that target SARS-CoV-2 …

[HTML][HTML] DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD-independent or dependent approach

AP Silwal, SKS Thennakoon, SP Arya, RM Postema… - Theranostics, 2022 - ncbi.nlm.nih.gov
Objective: Nobody knows when the COVID-19 pandemic will end or when and where the
next coronavirus will outbreak. Therefore, it is still necessary to develop SARS-CoV-2 …

SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells

K Yang, S Liu, H Yan, W Lu, X Shan, H Chen… - … and Targeted Therapy, 2023 - nature.com
Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2
significantly influences endothelial cells and induces pulmonary vascular endotheliopathy …