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The growing concern of chlorpyrifos exposures on human and environmental health
Chlorpyrifos (CP) and its highly electrophilic intermediates are principal toxic metabolites.
The active form of CP ie chlorpyrifos oxon (CP-oxon) is responsible for both the insecticidal …
The active form of CP ie chlorpyrifos oxon (CP-oxon) is responsible for both the insecticidal …
Improving the human hazard characterization of chemicals: a Tox21 update
RR Tice, CP Austin, RJ Kavlock… - Environmental health …, 2013 - ehp.niehs.nih.gov
Background: In 2008, the National Institute of Environmental Health Sciences/National
Toxicology Program, the US Environmental Protection Agency's National Center for …
Toxicology Program, the US Environmental Protection Agency's National Center for …
The next generation blueprint of computational toxicology at the US Environmental Protection Agency
Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …
ToxCast chemical landscape: paving the road to 21st century toxicology
The US Environmental Protection Agency's (EPA) ToxCast program is testing a large library
of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to …
of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to …
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …
potential to accelerate the pace of human health safety evaluation by informing screening …
An overview of machine learning and big data for drug toxicity evaluation
Drug toxicity evaluation is an essential process of drug development as it is reportedly
responsible for the attrition of approximately 30% of drug candidates. The rapid increase in …
responsible for the attrition of approximately 30% of drug candidates. The rapid increase in …
Trust, but verify: on the importance of chemical structure curation in cheminformatics and QSAR modeling research
Molecular modelers and cheminformaticians typically analyze experimental data generated
by other scientists. Consequently, when it comes to data accuracy, cheminformaticians are …
by other scientists. Consequently, when it comes to data accuracy, cheminformaticians are …
Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management
The field of toxicology is on the cusp of a major transformation in how the safety and hazard
of chemicals are evaluated for potential effects on human health and the environment …
of chemicals are evaluated for potential effects on human health and the environment …
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …
on the market in Europe after 2013. In that context, the European Commission invited …
Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA
Tens-of-thousands of chemicals are registered in the US for use in countless processes and
products. Recent evidence suggests that many of these chemicals are measureable in …
products. Recent evidence suggests that many of these chemicals are measureable in …