Cognitive impairment and World Trade Centre-related exposures

SAP Clouston, CB Hall, M Kritikos, DA Bennett… - Nature Reviews …, 2022 - nature.com
Abstract On 11 September 2001 the World Trade Center (WTC) in New York was attacked
by terrorists, causing the collapse of multiple buildings including the iconic 110-story 'Twin …

World Trade Center health program: First decade of research

A Santiago-Colón, R Daniels, D Reissman… - International journal of …, 2020 - mdpi.com
The terrorist attacks on 11 September 2001 placed nearly a half million people at increased
risk of adverse health. Health effects research began shortly after and continues today, now …

Incidence of mild cognitive impairment in World Trade Center responders: long‐term consequences of re‐experiencing the events on 9/11/2001

SAP Clouston, ED Diminich, R Kotov… - Alzheimer's & …, 2019 - Wiley Online Library
Objective This study examined whether World Trade Center (WTC) exposures and chronic
posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive …

Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans

ZE Neale, JR Fonda, MW Miller, EJ Wolf… - Alzheimer's research & …, 2024 - Springer
Background Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are
associated with self-reported problems with cognition as well as risk for Alzheimer's disease …

Reduced cortical thickness in World Trade Center responders with cognitive impairment

SAP Clouston, Y Deri, M Horton, C Tang… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction This study examined cortical thickness (CTX) in World Trade Center (WTC)
responders with cognitive impairment (CI). Methods WTC responders (N= 99) with/without …

PTSD is associated with accelerated transcriptional aging in World Trade Center responders

PF Kuan, X Ren, S Clouston, X Yang, K Jonas… - Translational …, 2021 - nature.com
Posttraumatic stress disorder (PTSD) is associated with shortened lifespan and healthspan,
which suggests accelerated aging. Emerging evidence suggests that methylation age may …

[HTML][HTML] Neuroinflammation in World Trade Center responders at midlife: a pilot study using [18F]-FEPPA PET imaging

Y Deri, SAP Clouston, C DeLorenzo… - Brain, Behavior, & …, 2021 - Elsevier
Background Neuroinflammation has long been theorized to arise from exposures to fine
particulate matter and to be modulated when individuals experience chronic stress, both of …

Exposure to world trade center dust exacerbates cognitive impairment and evokes a central and peripheral pro-inflammatory transcriptional profile in an animal model …

R Iban-Arias, KJ Trageser, EJ Yang… - Journal of …, 2023 - content.iospress.com
Background: The terrorist attacks on September 11, 2001, on the World Trade Center (WTC)
led to intense fires and a massive dense cloud of toxic gases and suspended pulverized …

Molecular linkage between post-traumatic stress disorder and cognitive impairment: a targeted proteomics study of World Trade Center responders

PF Kuan, S Clouston, X Yang, R Kotov… - Translational …, 2020 - nature.com
Existing work on proteomics has found common biomarkers that are altered in individuals
with post-traumatic stress disorder (PTSD) and mild cognitive impairment (MCI). The current …

Altered gene expression and PTSD symptom dimensions in World Trade Center responders

S Marchese, L Cancelmo, O Diab, L Cahn… - Molecular …, 2022 - nature.com
Despite experiencing a significant trauma, only a subset of World Trade Center (WTC)
rescue and recovery workers developed posttraumatic stress disorder (PTSD). Identification …