Combination drugs are an important class of US FDA approved pharmaceuticals. These
drugs have been on a continuous growth trajectory since the first combination drugs were …

Gout is characterized by hyperuricemia and the deposition of monosodium urate (MSU)
crystals around joints. Despite the availability of several drugs on the market, its treatment …

Zn‐based solid polymer electrolytes (SPEs) have enormous potential in realizing high‐
performance zinc‐ion batteries. Polymeric single‐ion conductor (PSIC)‐based SPEs can …

This short review compiles the main results of the studies in tetrazole chemistry published in
the period 2009–2016. Attention is directed to the structure, reactivity, synthetic problems …

Herein we report the facile syntheses of tetrazoles enabled by FSO2N3 under mild
conditions. FSO2N3 has been shown as the most powerful diazotizing reagent, which …

Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

The unique physicochemical properties and fascinating bioisosterism of tetrazole scaffolds
have received significant attention in medicinal chemistry. We report recent efforts using …

Lead optimization represents the tedious process of fine‐tuning lead compounds from
biologically active hits to suitable drug candidates for clinical trials. By chemically modifying …

Tetrazole cycle is a promising pharmacophore fragment frequently used in the development
of novel drugs. This moiety is a stable, practically non-metabolized bioisosteric analog of …

The review summarizes the advances in medicinal chemistry of tetrazole biologically active
compounds and drugs over the past 15 years. Most of the considered compounds are at …