Ferroptosis: a double-edged sword mediating immune tolerance of cancer

Q Dang, Z Sun, Y Wang, L Wang, Z Liu, X Han - Cell death & disease, 2022 - nature.com
The term ferroptosis was put forward in 2012 and has been researched exponentially over
the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed …

Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment

M Marzagalli, ND Ebelt, ER Manuel - Seminars in cancer biology, 2019 - Elsevier
Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …

The influence of tumor microenvironment on immune escape of melanoma

A Simiczyjew, E Dratkiewicz, J Mazurkiewicz… - International Journal of …, 2020 - mdpi.com
The low efficiency of currently-used anti-cancer therapies poses a serious challenge,
especially in the case of malignant melanoma, a cancer characterized by elevated …

[HTML][HTML] Abrogation of HnRNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8+ T cell-mediated ferroptosis in castration-resistant …

X Zhou, L Zou, H Liao, J Luo, T Yang, J Wu… - … Pharmaceutica Sinica B, 2022 - Elsevier
Owing to incurable castration-resistant prostate cancer (CRPC) ultimately develo** after
treating with androgen deprivation therapy (ADT), it is vital to devise new therapeutic …

Mechanisms of melanoma progression and treatment resistance: Role of cancer stem-like cells

Y Al Hmada, RT Brodell, N Kharouf, TW Flanagan… - Cancers, 2024 - mdpi.com
Simple Summary Melanoma is the third most common type of skin cancer. Melanoma is a
heterogeneous tumor, composed of genetically divergent subpopulations. These …

Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy

CA Shirley, G Chhabra, D Amiri, H Chang… - Frontiers in …, 2024 - frontiersin.org
Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary
introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain …

Network models of primary melanoma microenvironments identify key melanoma regulators underlying prognosis

WM Song, P Agrawal, R Von Itter… - Nature …, 2021 - nature.com
Melanoma is the most lethal skin malignancy, driven by genetic and epigenetic alterations in
the complex tumour microenvironment. While large-scale molecular profiling of melanoma …

Current knowledge of immunosuppression as a risk factor for skin cancer development

MP Rollan, R Cabrera, RA Schwartz - Critical Reviews in Oncology …, 2022 - Elsevier
This review outlines our current understanding of the relationship between
immunosuppression and skin cancer. Primary immunodeficiencies increase the incidence of …

FoxP3, CTLA-4, and IDO in canine melanocytic tumors

I Porcellato, C Brachelente, K Cappelli… - Veterinary …, 2021 - journals.sagepub.com
Despite promising immunotherapy strategies in human melanoma, there are few studies on
the immune environment of canine melanocytic tumors. In humans, the activation of …

Combination of attenuated Salmonella carrying PD‐1 siRNA with nifuroxazide for colon cancer therapy

T Zhao, Y Feng, M Guo, C Zhang, Q Wu… - Journal of Cellular …, 2020 - Wiley Online Library
Colon cancer is a member of malignant tumors in the digestive system. Traditional treatment
strategies are ineffective and improving the treatment of colon cancer is an urgent need …