In contrast to the wealth of proven therapies for heart failure with reduced ejection fraction
(HFrEF), therapeutic efforts in the past have failed to improve outcomes in heart failure with …

Nitric oxide (NO) is a powerful mediator with biological activities such as vasodilation and
prevention of vascular smooth muscle cell proliferation as well as functional regulation of …

The β3‐adrenoceptor was initially an attractive target for several pharmaceutical companies
due to its high expression in rodent adipose tissue, where its activation resulted in …

Heart failure with preserved ejection fraction (HFpEF) is a major unmet medical need that is
characterized by the presence of multiple cardiovascular and non-cardiovascular …

A major player in the homeostatic response to hypoxia is the hypoxia-inducible factor (HIF)-1
that transactivates a number of genes involved in neovessel proliferation in response to low …

Annually, peripheral arterial disease is estimated to cost over USD 21 billion and diabetic
foot disease an estimated at USD 9–13 billion. Mirabegron is a TGA-approved beta-3 …

Hydraulic fracturing is used to access oil and natural gas reserves. This process involves the
high-pressure injection of fluid to fracture shale. Fracking fluid contains approximately 95 …

As heart failure (HF) is a growing public health problem worldwide, rapid therapeutic
development is required to improve HF management. Decreased myocardial contractility in …

Despite the effectiveness of doxorubicin (DOXO) as a chemotherapeutic agent, dose-
dependent development of chronic cardiotoxicity limits its application. The angiotensin-II …

Objective Inhalation of diesel exhaust (DE) has been shown to be an occupational hazard in
the transportation, mining, and gas and oil industries. DE also contributes to air pollution …