Fear memory

I Izquierdo, CRG Furini, JC Myskiw - Physiological reviews, 2016 - journals.physiology.org
Fear memory is the best-studied form of memory. It was thoroughly investigated in the past
60 years mostly using two classical conditioning procedures (contextual fear conditioning …

More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans-Biological, experiential, temperamental factors, and …

TB Lonsdorf, CJ Merz - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Why do only some individuals develop pathological anxiety following adverse events? Fear
acquisition, extinction and return of fear paradigms serve as experimental learning models …

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

JM Mitchell, M Bogenschutz, A Lilienstein, C Harrison… - Focus, 2023 - Am Psychiatric Assoc
Post-traumatic stress disorder (PTSD) presents a major public health problem for which
currently available treatments are modestly effective. We report the findings of a randomized …

[HTML][HTML] Directed evolution of a selective and sensitive serotonin sensor via machine learning

EK Unger, JP Keller, M Altermatt, R Liang, A Matsui… - Cell, 2020 - cell.com
Serotonin plays a central role in cognition and is the target of most pharmaceuticals for
psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will …

[HTML][HTML] Sufficiency of mesolimbic dopamine neuron stimulation for the progression to addiction

V Pascoli, J Terrier, A Hiver, C Lüscher - Neuron, 2015 - cell.com
The factors causing the transition from recreational drug consumption to addiction remain
largely unknown. It has not been tested whether dopamine (DA) is sufficient to trigger this …

The role of dietary nutrients in inflammatory bowel disease

K Sugihara, TL Morhardt, N Kamada - Frontiers in immunology, 2019 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease of the
gastrointestinal tract. Although the precise etiology of IBD remains incompletely understood …

The role of Serotonin in fear learning and memory: A systematic review of human studies

F Tortora, AL Hadipour, S Battaglia, A Falzone… - Brain Sciences, 2023 - mdpi.com
Fear is characterized by distinct behavioral and physiological responses that are essential
for the survival of the human species. Fear conditioning (FC) serves as a valuable model for …

5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption

J Ma, R Wang, Y Chen, Z Wang, Y Dong - Journal of Neuroinflammation, 2023 - Springer
Background The microbiota–gut–brain axis plays an important role in the development of
depression. The aim of this study was to investigate the effects of 5-HT on cognitive function …

Physical activity promotes brain development through serotonin during early childhood

JQ **g, SJ Jia, CJ Yang - Neuroscience, 2024 - Elsevier
Early childhood serves as a critical period for neural development and skill acquisition when
children are extremely susceptible to the external environment and experience. As a crucial …

Anxiety and depression: A top‐down, bottom‐up model of circuit function

DO LeDuke, M Borio, R Miranda… - Annals of the New York …, 2023 - Wiley Online Library
A functional interplay of bottom‐up and top‐down processing allows an individual to
appropriately respond to the dynamic environment around them. These processing …