Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Novel approaches are required to address the looming threat of pan-resistant Gram-
negative pathogens and forestall the rise of untreatable infections. Unconventional targets …

Treating multidrug-resistant infections has increasingly relied on last-resort antibiotics,
including polymyxins, for example colistin. As polymyxins are given routinely, the prevalence …

Summary β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the
bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding proteins (PBPs). It …

Bloodstream infection is a major public health concern associated with high mortality and
high healthcare costs worldwide. Bacteremia can trigger fatal sepsis whose prevention …

Antimicrobial contamination and antimicrobial resistance have become global
environmental and health problems. A large number of antimicrobials are used in medical …

Identification of new antibiotics remains a huge challenge. The last antibiotic of new
chemical class and mechanism was discovered more than 30 years ago. Advances since …

Central metabolism is a topic that has been studied for decades, and yet, this process is still
not fully understood in Escherichia coli, perhaps the most amenable and well-studied model …

Pseudomonas aeruginosa is an opportunistic pathogen that predominantly causes
nosocomial and community-acquired lung infections. As a member of ESKAPE pathogens …

Essential genes encode the processes that are necessary for life. Until recently, commonly
applied binary classifications left no space between essential and non-essential genes. In …