Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer's disease

R Dhapola, P Sarma, B Medhi, A Prakash… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder which leads to mental
deterioration due to aberrant accretion of misfolded proteins in the brain. According to …

Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7

Q Hu, X He, Y Ma, L Ma, S Qu, H Wang, Y Kang… - Purinergic …, 2023 - Springer
Diabetic neuropathic pain (DNP) is highly common in diabetes patients. P2X receptors play
critical roles in pain sensitization. We previously showed that elevated P2X3 expression in …

Antidepressant effect of carvedilol on streptozotocin-induced diabetic peripheral neuropathy mice by altering gut microbiota

W Wu, C Zeng, C Wu, T Wu, J Pang, P Zhou… - Biochemical and …, 2024 - Elsevier
Rationale Although diabetic peripheral neuropathic pain (DPNP) and depression have been
recognized for many years, their co-morbidity relationship and effective treatment choices …

Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination

GI Fouad, KA Ahmed - International Immunopharmacology, 2023 - Elsevier
Multiple sclerosis (MS) is a complex and multifactorial neurodegenerative disease with
unknown etiology, MS is featured by multifocal demyelinated lesions distributed throughout …

Neuroprotective repositioning and anti-tau effect of carvedilol on rotenone induced neurotoxicity in rats: Insights from an insilico& in vivo anti-Parkinson's disease …

RE Kamal, E Menze, A Albohy, HI Ahmed… - European Journal of …, 2022 - Elsevier
Current treatments for Parkinson's Disease (PD) only provide symptomatic relief; however,
they don't delay the disease progression, hence new treatment options should be …

Neuroprotective Effect of Red Sea Marine Sponge Xestospongia testudinaria Extract Using In Vitro and In Vivo Diabetic Peripheral Neuropathy Models

R Magadmi, K Borouk, DTA Youssef, LA Shaala… - Pharmaceuticals, 2022 - mdpi.com
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes. Oxidative
stress plays an important role in the pathophysiology of DPN. Red Sea marine sponge …

Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male wistar rats: distinct effects on β-arrestin2 expression and molecular …

RMSM Mohamed, E Ahmad Ahmad, DM Amin… - DARU Journal of …, 2024 - Springer
Background Dexamethasone-induced neurotoxicity has been previously reported. However,
the molecular mechanisms are still not completely understood. Objectives The current work …

Hemoglobin glycation increases the electric charges on red blood cells: Effects of dielectric polarization

S Abdalla, F Farsaci, E Tellone, W Shirbeeny… - Materials Chemistry and …, 2022 - Elsevier
It is generally accepted that the glycated hemoglobin (HbA1c) is an efficient marker of
glucose accumulating during certain period in order to efficiently detect diabetes disorder …

Comprehensive review of animal models in diabetes research using chemical agents

S Algul, O Ozcelik - Laboratory Animals, 2025 - journals.sagepub.com
Diabetes mellitus, characterized by insufficient insulin secretion and impaired insulin
efficacy, disrupts carbohydrate, protein, and lipid metabolism. The global diabetic population …

Chemical Profile and Potential Application of Agri‐food Waste Products for Counteracting Diabetes Induced Neuropathy in Rats

SS El Souda, HH Ahmed, AA Maamoun… - Chemistry & …, 2024 - Wiley Online Library
This study aimed to prepare defatted ethanol extract of Abelmoschus esculentus leaves,
Morus nigra leaves and Punica granatum peel, to identify the chemical composition of these …