Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder which leads to mental
deterioration due to aberrant accretion of misfolded proteins in the brain. According to …
deterioration due to aberrant accretion of misfolded proteins in the brain. According to …
Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7
Q Hu, X He, Y Ma, L Ma, S Qu, H Wang, Y Kang… - Purinergic …, 2023 - Springer
Diabetic neuropathic pain (DNP) is highly common in diabetes patients. P2X receptors play
critical roles in pain sensitization. We previously showed that elevated P2X3 expression in …
critical roles in pain sensitization. We previously showed that elevated P2X3 expression in …
Antidepressant effect of carvedilol on streptozotocin-induced diabetic peripheral neuropathy mice by altering gut microbiota
W Wu, C Zeng, C Wu, T Wu, J Pang, P Zhou… - Biochemical and …, 2024 - Elsevier
Rationale Although diabetic peripheral neuropathic pain (DPNP) and depression have been
recognized for many years, their co-morbidity relationship and effective treatment choices …
recognized for many years, their co-morbidity relationship and effective treatment choices …
Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination
Multiple sclerosis (MS) is a complex and multifactorial neurodegenerative disease with
unknown etiology, MS is featured by multifocal demyelinated lesions distributed throughout …
unknown etiology, MS is featured by multifocal demyelinated lesions distributed throughout …
Neuroprotective repositioning and anti-tau effect of carvedilol on rotenone induced neurotoxicity in rats: Insights from an insilico& in vivo anti-Parkinson's disease …
Current treatments for Parkinson's Disease (PD) only provide symptomatic relief; however,
they don't delay the disease progression, hence new treatment options should be …
they don't delay the disease progression, hence new treatment options should be …
Neuroprotective Effect of Red Sea Marine Sponge Xestospongia testudinaria Extract Using In Vitro and In Vivo Diabetic Peripheral Neuropathy Models
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes. Oxidative
stress plays an important role in the pathophysiology of DPN. Red Sea marine sponge …
stress plays an important role in the pathophysiology of DPN. Red Sea marine sponge …
Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male wistar rats: distinct effects on β-arrestin2 expression and molecular …
RMSM Mohamed, E Ahmad Ahmad, DM Amin… - DARU Journal of …, 2024 - Springer
Background Dexamethasone-induced neurotoxicity has been previously reported. However,
the molecular mechanisms are still not completely understood. Objectives The current work …
the molecular mechanisms are still not completely understood. Objectives The current work …
Hemoglobin glycation increases the electric charges on red blood cells: Effects of dielectric polarization
It is generally accepted that the glycated hemoglobin (HbA1c) is an efficient marker of
glucose accumulating during certain period in order to efficiently detect diabetes disorder …
glucose accumulating during certain period in order to efficiently detect diabetes disorder …
Comprehensive review of animal models in diabetes research using chemical agents
Diabetes mellitus, characterized by insufficient insulin secretion and impaired insulin
efficacy, disrupts carbohydrate, protein, and lipid metabolism. The global diabetic population …
efficacy, disrupts carbohydrate, protein, and lipid metabolism. The global diabetic population …
Chemical Profile and Potential Application of Agri‐food Waste Products for Counteracting Diabetes Induced Neuropathy in Rats
SS El Souda, HH Ahmed, AA Maamoun… - Chemistry & …, 2024 - Wiley Online Library
This study aimed to prepare defatted ethanol extract of Abelmoschus esculentus leaves,
Morus nigra leaves and Punica granatum peel, to identify the chemical composition of these …
Morus nigra leaves and Punica granatum peel, to identify the chemical composition of these …