Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Most neurodegenerative diseases are proteinopathies, which are characterized by the
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …

Familial Alzheimer's disease (FAD), caused by mutations in Presenilin (PSEN1/2) and
Amyloid Precursor Protein (APP) genes, is associated with an early age at onset (AAO) of …

The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …

Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Amyloid-β peptide (Aβ) forms metastable oligomers> 50 kDa, termed AβOs, that are more
effective than Aβ amyloid fibrils at triggering Alzheimer's disease-related processes such as …

The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally
active intracellular domain, on force to unfold a protective domain and permit proteolysis, on …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …