Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

Significance: The selenium-containing Glutathione peroxidases (GPxs) 1–4 protect against
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …

Methods to direct the degradation of protein targets with proximity-inducing molecules that
coopt the cellular degradation machinery are advancing in leaps and bounds, and diverse …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Skeletal dysplasias are a diverse group of heritable diseases affecting bone and cartilage
growth. Throughout the years, the molecular defect underlying many of the diseases has …

Peroxisome‐proliferator activator receptor γ (PPARγ) is a nuclear receptor of central
importance in energy homeostasis and inflammation. Recent experimental pieces of …

Reactive oxygen species (ROS) have been regarded as harmful molecules that damage
various molecules inside cells by oxidation and are responsible for ageing and various …

Locus heterogeneity characterizes a variety of skeletal dysplasias often due to interacting or
overlap** signaling pathways. Robinow syndrome is a skeletal disorder historically …

The promise of engineering specific cell types from stem cells and rebuilding damaged or
diseased tissues has fascinated stem cell researchers and clinicians over last few decades …

Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several
adult connective tissues. MSCs possess the ability to self-renew and differentiate into …