The application of virus-like particles as vaccines and biological vehicles

D Yan, YQ Wei, HC Guo, SQ Sun - Applied Microbiology and …, 2015 - Springer
Virus-like particles (VLPs) can be spontaneously self-assembled by viral structural proteins
under appropriate conditions in vitro while excluding the genetic material and potential …

Virus-like particles produced in plants as potential vaccines

N Scotti, EP Rybicki - Expert review of vaccines, 2013 - Taylor & Francis
Virus-like particles (VLPs) have been produced as candidate vaccines in plants virtually
since the introduction of biofarming. Even today, VLPs remain the best candidates for safe …

Bioengineering of virus-like particles as dynamic nanocarriers for in vivo delivery and targeting to solid tumours

IFBM Suffian, KT Al-Jamal - Advanced Drug Delivery Reviews, 2022 - Elsevier
Virus-like particles (VLPs) are known as self-assembled, non-replicative and non-infectious
protein particles, which imitate the formation and structure of original wild type viruses …

Plant-derived VLP: a worthy platform to produce vaccine against SARS-CoV-2

F Hemmati, M Hemmati-Dinarvand, M Karimzade… - Biotechnology …, 2022 - Springer
After its emergence in late 2019 SARS-CoV-2 was declared a pandemic by the World Health
Organization on 11 March 2020 and has claimed more than 2.8 million lives. There has …

Virus-like particle-based nanocarriers as an emerging platform for drug delivery

B Yuan, Y Liu, M Lv, Y Sui, S Hou, T Yang… - Journal of Drug …, 2023 - Taylor & Francis
New nanocarrier technologies are emerging, and they have great potential for improving
drug delivery, targeting efficiency and bioavailability. Virus-like particles (VLPs) are natural …

A modular and self-adjuvanted multivalent vaccine platform based on porcine circovirus virus-like nanoparticles

ZH Liu, ZF Deng, Y Lu, WH Fang, F He - Journal of Nanobiotechnology, 2022 - Springer
Abstract Background Virus-like particles (VLPs) are supramolecular structures composed of
multiple protein subunits and resemble natural virus particles in structure and size, making …

pH-responsive virus-like nanoparticles with enhanced tumour-targeting ligands for cancer drug delivery

R Biabanikhankahdani, NBM Alitheen, KL Ho… - Scientific reports, 2016 - nature.com
Multifunctional nanocarriers harbouring specific targeting moieties and with pH-responsive
properties offer great potential for targeted cancer therapy. Several synthetic drug carriers …

Thermally-responsive virus-like particle for targeted delivery of cancer drug

QX Thong, R Biabanikhankahdani, KL Ho… - Scientific reports, 2019 - nature.com
Multifunctional nanocarriers displaying specific ligands and simultaneously response to
stimuli offer great potentials for targeted and controlled drug delivery. Several synthetic …

Targeted delivery of cell penetrating peptide virus-like nanoparticles to skin cancer cells

BK Gan, CY Yong, KL Ho, AR Omar, NB Alitheen… - Scientific Reports, 2018 - nature.com
Skin cancer or cutaneous carcinoma, is a pre-eminent global public health problem with no
signs of plateauing in its incidence. As the most common treatments for skin cancer, surgical …

Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy

N Ferrer-Miralles, E Rodríguez-Carmona… - Critical reviews in …, 2015 - Taylor & Francis
Lack of targeting and improper biodistribution are major flaws in current drug-based
therapies that prevent reaching high local concentrations of the therapeutic agent. Such …