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Mitohormesis
For many years, mitochondria were viewed as semiautonomous organelles, required only
for cellular energetics. This view has been largely supplanted by the concept that …
for cellular energetics. This view has been largely supplanted by the concept that …
Mitochondrial ribosomes in cancer
Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells.
They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) …
They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) …
SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation
Synchronization of mitochondrial and cytoplasmic translation rates is critical for the
maintenance of cellular fitness, with cancer cells being especially vulnerable to translational …
maintenance of cellular fitness, with cancer cells being especially vulnerable to translational …
[HTML][HTML] Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon
The mitochondrial electron transport chain is a major source of reactive oxygen species
(ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia …
(ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia …
Mitochondrial pathology: stress signals from the energy factory
Mitochondria are undergoing a renaissance. The cellular power plant is now recognized as
a key cellular signaling platform. The signals released by mitochondria are currently an area …
a key cellular signaling platform. The signals released by mitochondria are currently an area …
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness
Mitochondrial ribosomes synthesize a subset of hydrophobic proteins required for assembly
of the oxidative phosphorylation complexes. This process requires temporal and spatial …
of the oxidative phosphorylation complexes. This process requires temporal and spatial …
Control of retrograde signaling by rapid turnover of GENOMES UNCOUPLED1
The exchange of signals between cellular compartments coordinates development and
differentiation, modulates metabolic pathways, and triggers responses to environmental …
differentiation, modulates metabolic pathways, and triggers responses to environmental …
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination
Here, we report that acute reduction in mitochondrial translation fidelity (MTF) causes
ubiquitination of the inner mitochondrial membrane (IMM) proteins, including TRAP1 and …
ubiquitination of the inner mitochondrial membrane (IMM) proteins, including TRAP1 and …
Protein import into plant mitochondria: signals, machinery, processing, and regulation
The majority of more than 1000 proteins present in mitochondria are imported from nuclear-
encoded, cytosolically synthesized precursor proteins. This impressive feat of transport and …
encoded, cytosolically synthesized precursor proteins. This impressive feat of transport and …
The molecular pathology of pathogenic mitochondrial tRNA variants
Mitochondrial diseases are clinically and genetically heterogeneous disorders, caused by
pathogenic variants in either the nuclear or mitochondrial genome. This heterogeneity is …
pathogenic variants in either the nuclear or mitochondrial genome. This heterogeneity is …