It is now well known that non-coding RNAs (ncRNAs), rather than protein-coding transcripts,
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …

Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …

Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

Long non-coding RNAs (lncRNAs) were, once, viewed as “noise” for transcription. Recently,
many lncRNAs are functionally linked to several human disorders, including cancer. Coiled …

One of the most unexpected discoveries in molecular oncology, in the last decades, was the
identification of a new layer of protein coding gene regulation by transcripts that do not …

Colorectal cancer (CRC) is one of the most frequent cancers in incidence and mortality.
Despite advances in cancer biology, molecular genetics, and targeted treatments, CRC …

The majority of the genome is transcribed into pieces of non-(protein) coding RNA, among
which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile …

Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen
species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven …