Understanding the development and dysfunction of the human brain is a major goal of
neurobiology. Much of our current understanding of human brain development has been …

Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

We address the challenge of detecting the contribution of noncoding mutations to disease
with a deep-learning-based framework that predicts the specific regulatory effects and the …

Studying the function of common genetic variants in primary human tissues and during
development is challenging. To address this, we use an efficient multiplexing strategy to …

Notch signaling can have either an oncogenic or tumor-suppressive function in cancer
depending on the cancer type and cellular context. While Notch can be oncogenic in early …

Small cell lung carcinoma (SCLC) is a high-grade pulmonary neuroendocrine tumor. The
transcription factors ASCL1 and NEUROD1 play crucial roles in promoting malignant …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Organoids derived from human pluripotent stem cells recapitulate the early three-
dimensional organization of the human brain, but whether they establish the epigenomic …

Recently, direct reprogramming between divergent lineages has been achieved by the
introduction of regulatory transcription factors. This approach may provide alternative cell …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …