Integrating Large-Scale Protein Structure Prediction into Human Genetics Research

M Correa Marrero, J Jänes, D Baptista… - Annual Review of …, 2024 - annualreviews.org
The last five years have seen impressive progress in deep learning models applied to
protein research. Most notably, sequence-based structure predictions have seen …

Integrating Large-Scale Protein Structure Prediction into Human Genetics Research

J Jänes, D Baptista, P Beltrao - Annual review of …, 2024 - research-collection.ethz.ch
The last five years have seen impressive progress in deep learning models applied to
protein research. Most notably, sequence-based structure predictions have seen …

Structural insights into the mechanotransducing mechanism of FtsEX in cell division

Y Chen, D Guo, X Wang, C Zhang, Y Chen, Q Luo… - MedComm, 2024 - Wiley Online Library
The filamentous temperature‐sensitive (Fts) protein FtsEX plays a pivotal role in Escherichia
coli (E. coli) cell division by facilitating the activation of peptidoglycan hydrolysis through the …

Structure and activity of the septal peptidoglycan hydrolysis machinery crucial for bacterial cell division

Y Chen, J Gu, B Yang, L Yang, J Pang, Q Luo, Y Li… - Plos …, 2024 - journals.plos.org
The peptidoglycan (PG) layer is a critical component of the bacterial cell wall and serves as
an important target for antibiotics in both gram-negative and gram-positive bacteria. The …

Genome wide structural prediction of ABC transporter systems in Bacillus subtilis

A Mahendran, BJ Orlando - Frontiers in Microbiology, 2024 - frontiersin.org
ABC transporters are a diverse superfamily of membrane protein complexes that utilize the
binding/hydrolysis of ATP to power substrate movement across biological membranes or …

Modulation of the lytic apparatus by the F ts EX complex within the bacterial division machinery

M Alcorlo, S Martínez‐Caballero, J Li, LT Sham… - FEBS …, 2024 - Wiley Online Library
The FtsEX membrane complex constitutes an essential component of the ABC transporter
superfamily, widely distributed among bacterial species. It governs peptidoglycan …