Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Mesenchymal stem cell‐based immunomodulation: properties and clinical application

M Wang, Q Yuan, L **e - Stem cells international, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self‐renewal,
production of clonal cell populations, and multilineage differentiation. They exist in nearly all …

Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications

Y Wang, X Chen, W Cao, Y Shi - Nature immunology, 2014 - nature.com
Mesenchymal stem cells (MSCs) are multipotent stromal cells that exist in many tissues and
are capable of differentiating into several different cell types. Exogenously administered …

HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing

B Zhang, M Wang, A Gong, X Zhang, X Wu, Y Zhu… - Stem …, 2015 - academic.oup.com
Mesenchymal stem cell-derived exosomes (MSC-Ex) play important roles in tissue injury
repair, however, the roles of MSC-Ex in skin damage repair and its mechanisms are largely …

Interactions between mesenchymal stem cells and the immune system

N Li, J Hua - Cellular and Molecular Life Sciences, 2017 - Springer
In addition to being multi-potent, mesenchymal stem cells (MSCs) possess
immunomodulatory functions that have been investigated as potential treatments in various …

Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis

T Li, Y Yan, B Wang, H Qian, X Zhang… - Stem cells and …, 2013 - liebertpub.com
Mesenchymal stem cells (MSCs) have been considered as an attractive tool for the therapy
of diseases. Exosomes excreted from MSCs can reduce myocardial ischemia/reperfusion …

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

Y Zhou, H Xu, W Xu, B Wang, H Wu, Y Tao… - Stem cell research & …, 2013 - Springer
Introduction Administration of bone marrow mesenchymal stem cells (MSCs) or secreted
microvesicles improves recovery from acute kidney injury (AKI). However, the potential roles …

Exosomes derived from human umbilical cord mesenchymal stem cells relieve acute myocardial ischemic injury

Y Zhao, X Sun, W Cao, J Ma, L Sun… - Stem cells …, 2015 - Wiley Online Library
This study is aimed at investigating whether human umbilical cord mesenchymal stem cell‐
(hucMSC‐) derived exosomes (hucMSC‐exosomes) have a protective effect on acute …

A review of cellularization strategies for tissue engineering of whole organs

ME Scarritt, NC Pashos, BA Bunnell - Frontiers in bioengineering and …, 2015 - frontiersin.org
With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for
organ engineering were generated from numerous tissues, including the heart, lung, liver …

Exosomes derived from human umbilical cord mesenchymal stem cells relieve inflammatory bowel disease in mice

F Mao, Y Wu, X Tang, J Kang, B Zhang… - BioMed research …, 2017 - Wiley Online Library
Exosomes secreted by mesenchymal stem cells (MSCs) have shown repairing effects on
several tissue injury diseases. In this study, we aimed to investigate the effects of exosomes …