Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic
kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it …

Rationale: Ureteral obstruction-induced hydronephrosis is associated with renal fibrosis and
progressive chronic kidney disease (CKD). Exosome-mediated cell-cell communication has …

Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality
rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and …

Kidney fibrosis is associated with tubular injury, oxidative stress and activation of interstitial
fibroblasts. However, whether these events are somehow connected is poorly understood. In …

Renal fibrosis (RF) is the end stage of several chronic kidney diseases. Its series of changes
include excessive accumulation of extracellular matrix, epithelial-mesenchymal transition …