The role of histone deacetylase 3 complex in nuclear hormone receptor action

S Ishii - International journal of molecular sciences, 2021 - mdpi.com
Nuclear hormone receptors (NRs) regulate transcription of the target genes in a ligand-
dependent manner in either a positive or negative direction, depending on the case …

Chromatin remodeling of prostaglandin signaling in smooth muscle enables mouse embryo passage through the female reproductive tract

Q **n, G Yu, I Feng, J Dean - Developmental Cell, 2023 - cell.com
Early mammalian development occurs during embryo transit of the female reproductive tract.
Transport is orchestrated by secreted oviduct fluid, unidirectional beating of epithelial cilia …

SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

P Huang, W Deng, H Bao, Z Lin, M Liu, J Wu, X Zhou… - Elife, 2022 - elifesciences.org
The establishment of pregnancy in human necessitates appropriate decidualization of
stromal cells, which involves steroids regulated periodic transformation of endometrial …

Stromal Pbrm1 mediates chromatin remodeling necessary for embryo implantation in the mouse uterus

Q **n, I Feng, G Yu, J Dean - The Journal of Clinical …, 2024 - Am Soc Clin Investig
Early gestational loss occurs in approximately 20% of all clinically recognized human
pregnancies and is an important cause of morbidity. Either embryonic or maternal defects …

H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation

N Deng, G Li, L Zhang, P Wang, M Liu, B He… - Cell Death & …, 2024 - nature.com
Uterine luminal epithelia (LE), the first layer contacting with the blastocyst, acquire receptivity
for normal embryo implantation. Besides the well-accepted transcriptional regulation …

Structure-based virtual screening, molecular simulation and free energy calculations of traditional Chinese medicine, ZINC database revealed potent inhibitors of …

M Shahab, M Zulfat, G Zheng - Journal of Biomolecular Structure …, 2024 - Taylor & Francis
Breast Cancer, a heterogeneous disease at the molecular level, is the most common cause
of woman mortality worldwide. We used molecular screening and simulation approaches to …

Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors

E Thouennon, V Delfosse, R Bailly, P Blanc… - Cellular and Molecular …, 2019 - Springer
The estrogen-related receptor γ (ERRγ, NR3B3) is a constitutively active nuclear receptor
which has been proposed to act as a mediator of the low-dose effects of a number of …

Estrogens receptors, nuclear coactivator 1 and ligand-dependent corepressor expression are altered early during induced ovarian follicular persistence in dairy cattle

US Notaro, E Huber, AF Stassi, NE Ormaechea… - Theriogenology, 2023 - Elsevier
Failure of ovulation can lead to follicular persistence, one of the main components of the
pathogenesis of cystic ovarian disease (COD) in dairy cattle. Follicular persistence causes …

[HTML][HTML] Usp22 is expressed in mouse uterus during early pregnancy and involved in endometrial stromal cell decidualization

Y Wang, Y Gao, C Zhou, S Kong, H Wang, J Yang - Cells & Development, 2021 - Elsevier
While decidualization is essential for embryo implantation in the context of a normal
pregnancy, the molecular basis for this process remains poorly understood. Ubiquitin …

Impact of estrogen and progesterone receptor expression on the incidence of endometrial polyps

C Yan, C **ng, T Wei, H Zhou, H Wang… - Biomarkers in …, 2023 - Taylor & Francis
Aim: We studied the association of estrogen receptor (ER) and progesterone receptor (PR)
with endometrial polyp (EP) formation. Methods: A total of 129 EP patients and an equal …