Although homocysteine (Hcy) has been widely implicated in the etiology of various physical
health impairments, especially cardiovascular diseases, overwhelming evidence indicates …

Homocysteine (HCY), a physiological amino acid formed when proteins break down, leads
to a pathological condition called hyperhomocysteinemia (HHCY), when it is over a definite …

Major neuropsychiatric disorders are highly heritable, with mounting evidence suggesting
that these disorders share overlap** sets of molecular and cellular underpinnings. In the …

Purpose To evaluate the prevalence of abnormal vitamin B12, folate, total homocysteine
(tHcy), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) levels …

Given the moderate efficacy of the currently available antidepressants (ADs) in the treatment
of major depressive disorder (MDD), the identification of agents that are both able to …

Background: Bipolar disorder (BD) is a psychiatric disorder with an uncertain aetiology.
Recently, special attention has been given to homocysteine (Hcy), as it has been suggested …

The mood disorder prodrome is conceptualized as a symptomatic, but not yet clinically
diagnosable stage of an affective disorder. Although a growing area, more focused research …

Background Higher homocysteine (Hcy) level has been suggested to be associated with
major psychiatric disorders (MPDs), such as schizophrenia (SCZ), bipolar disorder (BD), and …

When training in neurology at the National Hospital, London in the mid-1960s, my first
research interest was on the effects of antiepileptic drugs (AEDs) on folate and vitamin B12 …

Background: Seasonal affective disorder (SAD) is a biological and mood disorder with a
seasonal pattern. Dietary intervention and nutritional status have been reported to affect …