Fluorinated phosphonates: Synthesis and biomedical application
The phosphate moiety (PO4-2) is the common structural motif of a wide range of natural
phosphorus-based biologically active compounds, which play important roles as metabolic …
phosphorus-based biologically active compounds, which play important roles as metabolic …
Nucleoside triphosphates—building blocks for the modification of nucleic acids
M Hollenstein - Molecules, 2012 - mdpi.com
Nucleoside triphosphates are moldable entities that can easily be functionalized at various
locations. The enzymatic polymerization of these modified triphosphate analogues …
locations. The enzymatic polymerization of these modified triphosphate analogues …
MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP
S Krukenberg, F Möckl, M Weiß, P Dekiert… - Nature …, 2024 - nature.com
Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate
(NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in …
(NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in …
Pronucleotides of 2′, 3′-Dideoxy-2′, 3′-Didehydrothymidine as Potent Anti-HIV Compounds
X Jia, D Schols, C Meier - Journal of Medicinal Chemistry, 2023 - ACS Publications
We report on the synthesis and evaluation of three different nucleotide prodrug systems:(i)
nucleoside triphosphate analogues in which the γ-phosph (on) ate has two different …
nucleoside triphosphate analogues in which the γ-phosph (on) ate has two different …
Membrane‐permeable Triphosphate Prodrugs of Nucleoside Analogues
T Gollnest, T Dinis de Oliveira, A Rath… - Angewandte Chemie …, 2016 - Wiley Online Library
The metabolic conversion of nucleoside analogues into their triphosphates often proceeds
insufficiently. Rate‐limitations can be at the mono‐, but also at the di‐and triphosphorylation …
insufficiently. Rate‐limitations can be at the mono‐, but also at the di‐and triphosphorylation …
Nucleotide analog ARL67156 as a lead structure for the development of CD39 and dual CD39/CD73 ectonucleotidase inhibitors
L Schäkel, CC Schmies, RM Idris, X Luo… - Frontiers in …, 2020 - frontiersin.org
Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential
as novel drugs for the (immuno) therapy of cancer. They increase the extracellular …
as novel drugs for the (immuno) therapy of cancer. They increase the extracellular …
Anti-HIV-active nucleoside triphosphate prodrugs
X Jia, D Schols, C Meier - Journal of Medicinal Chemistry, 2020 - ACS Publications
We disclose a study on nucleoside triphosphate (NTP) analogues in which the γ-phosphate
is covalently modified by two different biodegradable masking units and d4T as nucleoside …
is covalently modified by two different biodegradable masking units and d4T as nucleoside …
Iterative synthesis of nucleoside oligophosphates with phosphoramidites
GS Cremosnik, A Hofer… - Angewandte Chemie …, 2014 - Wiley Online Library
P‐Amidites can be used in iterative couplings to selectively give mixed PIII–PV anhydrides.
These intermediates can be oxidized followed by a rapid removal of the two terminal …
These intermediates can be oxidized followed by a rapid removal of the two terminal …
Beyond triphosphates: reagents and methods for chemical oligophosphorylation
Oligophosphates play essential roles in biochemistry, and considerable research has been
directed toward the synthesis of both naturally occurring oligophosphates and their synthetic …
directed toward the synthesis of both naturally occurring oligophosphates and their synthetic …
Sulfonyl imidazolium salts as reagents for the rapid and efficient synthesis of nucleoside polyphosphates and their conjugates
A procedure for the synthesis of nucleoside polyphosphates and their conjugates using
sulfonylimidazolium salts as key reagents is described. The procedure is rapid and high …
sulfonylimidazolium salts as key reagents is described. The procedure is rapid and high …