Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
BF Haynes, K Wiehe, P Borrow, KO Saunders… - Nature Reviews …, 2023 - nature.com
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
[HTML][HTML] Germinal center B cell dynamics
Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …
such are vitally important for humoral immunity. The study of GC biology has undergone a …
COVID-19 infection: implications for perioperative and critical care physicians
JR Greenland, MD Michelow, L Wang… - …, 2020 - pmc.ncbi.nlm.nih.gov
Healthcare systems worldwide are responding to Coronavirus Disease 2019 (COVID-19),
an emerging infectious syndrome caused by the Severe Acute Respiratory Syndrome …
an emerging infectious syndrome caused by the Severe Acute Respiratory Syndrome …
FUBAR: a fast, unconstrained bayesian approximation for inferring selection
Abstract Model-based analyses of natural selection often categorize sites into a relatively
small number of site classes. Forcing each site to belong to one of these classes places …
small number of site classes. Forcing each site to belong to one of these classes places …
Human circulating PD-1+ CXCR3− CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses
The vast majority of currently licensed human vaccines work on the basis of long-term
protective antibody responses. It is now conceivable that an antibody-dependent HIV …
protective antibody responses. It is now conceivable that an antibody-dependent HIV …
[HTML][HTML] Restricted clonality and limited germinal center reentry characterize memory B cell reactivation by boosting
Repeated exposure to pathogens or their antigens triggers anamnestic antibody responses
that are higher in magnitude and affinity than the primary response. These involve …
that are higher in magnitude and affinity than the primary response. These involve …
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …
Rational HIV immunogen design to target specific germline B cell receptors
Vaccine development to induce broadly neutralizing antibodies (bNAbs) against HIV-1 is a
global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 …
global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 …
The promise and challenge of high-throughput sequencing of the antibody repertoire
Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …
organs using high-throughput DNA sequencing technologies have been advancing at an …
Immune clearance of highly pathogenic SIV infection
SG Hansen, MP Jr, AB Ventura, CM Hughes… - Nature, 2013 - nature.com
Established infections with the human and simian immunodeficiency viruses (HIV and SIV,
respectively) are thought to be permanent with even the most effective immune responses …
respectively) are thought to be permanent with even the most effective immune responses …