Singlet molecular oxygen reactions with nucleic acids, lipids, and proteins
Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …
Formation and repair of oxidatively generated damage in cellular DNA
In this review article, emphasis is placed on the critical survey of available data concerning
modified nucleobase and 2-deoxyribose products that have been identified in cellular DNA …
modified nucleobase and 2-deoxyribose products that have been identified in cellular DNA …
[HTML][HTML] Role of estrogen and other sex hormones in brain aging. Neuroprotection and DNA repair
Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …
physiological function and increased susceptibility to disease. The detrimental effects of …
The role of carbonate in catalytic oxidations
Conspectus CO2, HCO3–, and CO32–are present in all aqueous media at pH> 4 if no major
effort is made to remove them. Usually the presence of CO2/HCO3–/CO32–is either …
effort is made to remove them. Usually the presence of CO2/HCO3–/CO32–is either …
Interplay of guanine oxidation and G-quadruplex folding in gene promoters
Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …
Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage
A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
Sequencing the mouse genome for the oxidatively modified base 8-oxo-7, 8-dihydroguanine by OG-Seq
Oxidative damage to the genome can yield the base 8-oxo-7, 8-dihydroguanine (OG). In
vitro studies suggested OG would preferentially form in 5′-GG-3′ sequence contexts after …
vitro studies suggested OG would preferentially form in 5′-GG-3′ sequence contexts after …
8-Oxo-7, 8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis
A high flux of reactive oxygen species during oxidative stress results in oxidative
modification of cellular components including DNA. Oxidative DNA “damage” to the …
modification of cellular components including DNA. Oxidative DNA “damage” to the …
On the relevance of hydroxyl radical to purine DNA damage
Hydroxyl radical (HO•) is the most reactive toward DNA among the reactive oxygen species
(ROS) generated in aerobic organisms by cellular metabolisms. HO• is generated also by …
(ROS) generated in aerobic organisms by cellular metabolisms. HO• is generated also by …
The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription
S Cogoi, A Ferino, G Miglietta… - Nucleic acids …, 2018 - academic.oup.com
KRAS is one of the most mutated genes in human cancer. It is controlled by a G4 motif
located upstream of the transcription start site. In this paper, we demonstrate that 8 …
located upstream of the transcription start site. In this paper, we demonstrate that 8 …