Hereditary factors account for a significant proportion of breast cancer risk. Approximately
20% of hereditary breast cancers are attributable to pathogenic variants in the highly …

Abstract Approximately 5–10% of breast cancer cases might be inheritable, up to 30% of
which are due to BRCA1/2 mutations. During the past few years and thanks to technology …

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …

Purpose The aim of the study was to update the description of Li-Fraumeni syndrome (LFS),
a remarkable cancer predisposition characterized by extensive clinical heterogeneity …

BACKGROUND As panel testing becomes more common in clinical practice, it is important
to understand the prevalence and trends associated with the pathogenic variants (PVs) …

Breast cancer is the most common tumor in women with Li-Fraumeni Syndrome (LFS), an
inherited cancer syndrome associated with germline mutations in the TP53 tumor …

Here, we show that a subset of breast cancers express high levels of the type 2
phosphatidylinositol-5-phosphate 4-kinases α and/or β (PI5P4Kα and β) and provide …

Approximately 10% of breast cancers are associated with the inheritance of a pathogenic
variant (PV) in one of the breast cancer susceptibility genes. Multiple breast cancer …

BACKGROUND: Germline TP53 mutations predispose to early onset breast cancer in
women and are associated with Li‐Fraumeni syndrome. Published data on the pathological …

Cancers cause significant mortality and morbidity in adolescents and young adults (AYAs),
but their biological underpinnings are incompletely understood. Here, we analyze clinical …