Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to
other delivery routes, including the most popular oral one. Due to the unique anatomical …

Nose to brain drug delivery is considered as a viable option to deliver various therapeutic
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …

The research was aimed to formulate the Donepezil (DPZ)-loaded nanostructured lipid
carriers (NLCs) and coated with chitosan (CH) for brain targeting through the intranasal …

Scientific research has focused its attention on finding an alternative route to systemic oral
and parenteral administration, to overcome their usual drawbacks, such as hepatic first-pass …

Liposomes modified with tetradecyltriphenylphosphonium bromide with dual loading of α-
tocopherol and donepezil hydrochloride were successfully designed for intranasal …

Intranasal administration is a drug delivery approach to provide a non-invasive
pharmacological response in the central nervous system with relatively small peripheral side …

Nasal administration has been demonstrated as an effective alternative for drug delivery to
central nervous system (CNS), especially for use in neurodegenerative diseases. Donepezil …

Alzheimer's disease (AD) is the fifth leading cause of death on the planet. It hallmarks the
presence of amyloid plaques and neurofibrillary tangles in geriatric patients. The condition …

Alzheimer's disease, a progressive neurodegenerative condition, is characterized by a
gradual decline in cognitive functions. Current treatment approaches primarily involve the …

Rivastigmine hydrogen tartrate (RIV-HT) is given orally for Alzheimer's disease. However,
oral therapy shows low brain bioavailability, short half-life and gastrointestinal-mediated …