The application of statistics has been instrumental in clarifying our understanding of the
genome. While insights have been derived for almost all levels of genome function, most …

Single-cell gene expression analyses of mammalian tissues have uncovered profound
stage-specific molecular regulatory phenomena that have changed the understanding of …

Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction
between the 3-to 8-cell stage, posing a significant clinical problem. The mechanisms behind …

Genetic susceptibility to intellectual disability (ID), autism spectrum disorder (ASD), and
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …

Abstract Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in
multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple …

Embryonic stem cells (ESCs), somatic cell nuclear transfer ESCs, and induced pluripotent
stem cells (iPSCs) represent the most studied group of PSCs. Unlimited self-renewal without …

Rapidly decreasing cost of next-generation sequencing has led to the recent availability of
large-scale RNA-seq data, that empowers the analysis of gene expression variability, in …

Robust predictive models are essential to manage the risk of radiation-induced
carcinogenesis. Chronic exposure to cosmic rays in the context of the complex deep space …

In this study, we identified copy number variants (CNVs) in 19 European autochthonous pig
breeds and in two commercial breeds (Italian Large White and Italian Duroc) that represent …

Gene expression in a tissue-specific context depends on the combined efforts of epigenetic,
transcriptional and post-transcriptional processes that lead to the production of specific …