Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Background Acute leukemias represent deadly malignancies that require better treatment.
As a challenge, treatment is counteracted by a microenvironment protecting dormant …

The biological regulation of transcription factors (TFs) and repressor proteins is an important
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …

Precision oncology relies on detailed molecular analysis of how diverse tumours respond to
various therapies, with the aim to optimize treatment outcomes for individual patients. Patient …

Regulated cell death predominantly involves apoptosis, autophagy, and regulated necrosis.
It is vital that we understand how key regulatory signals can control the process of cell death …

Cationic polymer polyethylenimine (PEI) plays a crucial role in gene delivery. However, high
molecular weight PEI leads to higher efficient transfection efficacy and higher cytotoxicity …

Acute lymphoblastic leukemia (ALL) represents the most frequent malignancy in children,
and relapse/refractory (r/r) disease is difficult to treat, both in children and adults. In search …

Translocations producing rearranged versions of the transcription factor double homeobox 4
(DUX4-r) are one of the most frequent causes of B cell acute lymphoblastic leukemia (B …

Acute myeloid leukemia with complex karyotype (ckAML) is characterized by high genomic
complexity, including frequent TP53 mutations and chromothripsis. We hypothesized that the …