Electrostatic interactions and protein competition reveal a dynamic surface in gold nanoparticle–protein adsorption

A Wang, YR Perera, MB Davidson… - The Journal of Physical …, 2016 - ACS Publications
Gold nanoparticle–(AuNP−) protein conjugates are potentially useful in a broad array of
diagnostic and therapeutic applications, but the physical basis of the simultaneous …

Role of free thiol on protein adsorption to gold nanoparticles

O Awotunde, S Okyem, R Chikoti, JD Driskell - Langmuir, 2020 - ACS Publications
Protein–gold nanoparticle (AuNP) bioconjugates have many potential applications in
nanomedicine. A thorough understanding of the interaction between the protein and the …

High-affinity points of interaction on antibody allow synthesis of stable and highly functional antibody–gold nanoparticle conjugates

S Okyem, O Awotunde, T Ogunlusi… - Bioconjugate …, 2021 - ACS Publications
Many emerging nanobiotechnologies rely on the proper function of proteins immobilized on
gold nanoparticles. Often, the surface chemistry of the AuNP is engineered to control the …

Probing the mechanism of antibody-triggered aggregation of gold nanoparticles

S Okyem, O Awotunde, T Ogunlusi, MKB Riley… - Langmuir, 2021 - ACS Publications
The unique physicochemical properties of gold nanoparticles (AuNPs) provide many
opportunities to develop novel biomedical technologies. The surface chemistry of AuNPs …

Predicting protein function and orientation on a gold nanoparticle surface using a residue-based affinity scale

JX Xu, MS Alom, R Yadav, NC Fitzkee - Nature Communications, 2022 - nature.com
The orientation adopted by proteins on nanoparticle surfaces determines the nanoparticle's
bioactivity and its interactions with living systems. Here, we present a residue-based affinity …

Facile displacement of citrate residues from gold nanoparticle surfaces

GS Perera, SA Athukorale, F Perez… - Journal of colloid and …, 2018 - Elsevier
The stability of citrate-residues on gold nanoparticles (AuNPs) against ligand displacement
has been controversial. Using AuNPs synthesized with deuterated citrate in combination …

Protein Binding Leads to Reduced Stability and Solvated Disorder in the Polystyrene Nanoparticle Corona

RP Somarathne, DL Amarasekara, CS Kariyawasam… - Small, 2024 - Wiley Online Library
Understanding the conformation of proteins in the nanoparticle corona has important
implications in how organisms respond to nanoparticle‐based drugs. These proteins coat …

Understanding protein structure deformation on the surface of gold nanoparticles of varying size

KE Woods, YR Perera, MB Davidson… - The Journal of …, 2016 - ACS Publications
Gold nanoparticles (AuNPs) have been of recent interest due to their unique optical
properties and their biocompatibility. Biomolecules spontaneously adsorb to their surface, a …

Controlled Temporal Release of Serum Albumin Immobilized on Gold Nanoparticles

T Ogunlusi, JD Driskell - Langmuir, 2023 - ACS Publications
Proteins adsorbed to gold nanoparticles (AuNPs) form bioconjugates and are critical to
many emerging technologies for drug delivery, diagnostics, therapies, and other biomedical …

Density functional investigation of the adsorption effects of PH3 and SH2 on the structure stability of the Au55 and Pt55 nanoclusters

D Guedes-Sobrinho, AS Chaves… - The Journal of …, 2017 - pubs.aip.org
Although several studies have been reported for Pt 55 and Au 55 nanoclusters, our atomistic
understanding of the interplay between the adsorbate-surface interactions and the …