Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

This review focuses on the unique clinical and molecular pharmacology of etomidate.
Among general anesthesia induction drugs, etomidate is the only imidazole, and it has the …

Although general anaesthesia has been of tremendous importance for the development of
surgery, the underlying mechanisms by which this state is achieved are only just beginning …

General anesthetics are widely used in clinical practice. On the molecular level, these
compounds have been shown to modulate the activity of various neuronal ion channels …

Propofol (2, 6-diisopropylphenol) is becoming the intravenous anesthetic of choice for
ambulatory surgery in outpatients. It is extensively metabolized, with most of the …

It is increasingly being appreciated that GABAA receptor subtypes, through their specific
regional, cellular and subcellular localization, are linked to distinct neuronal circuits and …

Propofol is the most important intravenous general anesthetic in current clinical use. It acts
by potentiating GABAA (γ-aminobutyric acid type A) receptors, but where it binds to this …