Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age
with a peak incidence in adolescents and young adults. The treatment of ES relies on a …

Context.—Current 2013 World Health Organization classification of tumors of soft tissue
arranges these tumors into 12 groups according to their histogenesis. Tumor behavior is …

The aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function
is not completely understood. We find that EWS-FLI1 reprograms gene regulatory circuits in …

Deciphering the ways in which somatic mutations and germline susceptibility variants
cooperate to promote cancer is challenging. Ewing sarcoma is characterized by fusions …

STAG2, a cohesin family gene, is among the most recurrently mutated genes in cancer.
STAG2 loss of function (LOF) is associated with aggressive behavior in Ewing sarcoma, a …

Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular
detection of pathognomonic EWSR1-ETS fusions such as EWSR1-FLI1 enables definitive …

Ewing's sarcoma (EWS) is a bone cancer arising predominantly in young children. EWSR1
(Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1) gene is ubiquitously …

Ewing's sarcoma is a highly malignant bone tumor found in children and adolescents, and
the origin of this malignancy is not well understood. Here, we introduced a Ewing's sarcoma …

Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors
converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although …

There is a great need to develop novel approaches to target oncogenic transcription factors
with small molecules. Ewing sarcoma is emblematic of this need, as it depends on the …