Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

Endosomes are dynamic intracellular compartments that control the sorting of a constant
stream of different transmembrane cargos either for ESCRT‐mediated degradation or for …

The global spread of SARS-CoV-2 is posing major public health challenges. One feature of
SARS-CoV-2 spike protein is the insertion of multi-basic residues at the S1/S2 subunit …

The Commander complex is required for endosomal recycling of diverse transmembrane
cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies …

Following endocytosis into the endosomal network, integral membrane proteins undergo
sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here …

The tubular endolysosomal network is a quality control system that ensures the proper
delivery of internalized receptors to specific subcellular destinations in order to maintain …

The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic
circulating low-density lipoprotein (LDL) cholesterol. Here we show that the …

Endosomes are major protein sorting stations in cells. Endosomally localised multi-protein
complexes sort integral proteins, including signaling receptors, nutrient transporters …

The recycling of membrane proteins from endosomes to the cell surface is vital for cell
signaling and survival. Retriever, a trimeric complex of vacuolar protein-sorting-associated …

Protein recycling through the endolysosomal system relies on molecular assemblies that
interact with cargo proteins, membranes, and effector molecules. Among them, the …