A One Health approach to overcoming fungal disease and antifungal resistance

M Woods, JA McAlister… - WIREs Mechanisms of …, 2023‏ - Wiley Online Library
The global burden of fungal disease poses a substantial threat to human, animal, and
environmental health, endangering both human and livestock populations and creating …

The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022‏ - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Signaling pathways for stress responses and adaptation in Aspergillus species: stress biology in the post-genomic era

D Hagiwara, K Sakamoto, K Abe… - Bioscience …, 2016‏ - academic.oup.com
Aspergillus species are among the most important filamentous fungi in terms of industrial
use and because of their pathogenic or toxin-producing features. The genomes of several …

[HTML][HTML] Antimicrobial activity of the peptide LfcinB15 against Candida albicans

CK Chang, MC Kao, CY Lan - Journal of Fungi, 2021‏ - mdpi.com
Lactoferricin (Lfcin) is an amphipathic, cationic peptide derived from proteolytic cleavage of
the N-lobe of lactoferrin (Lf). Lfcin and its derivatives possess broad-spectrum antibacterial …

[HTML][HTML] Cytokinin production and sensing in fungi

G Anand, R Gupta, I Marash, M Leibman-Markus… - Microbiological …, 2022‏ - Elsevier
Plant hormones act as chemical messengers, transducing cellular and organ-level cues,
executing plant growth, development, reproduction, metabolism, and response to …

[HTML][HTML] The molecular mechanism of fludioxonil action is different to osmotic stress sensing

K Bersching, S Jacob - Journal of Fungi, 2021‏ - mdpi.com
The group III two-component hybrid histidine kinase MoHik1p in the filamentous fungus
Magnaporthe oryzae is known to be a sensor for external osmotic stress and essential for …

The cystic fibrosis treatment Trikafta affects the growth, viability, and cell wall of Aspergillus fumigatus biofilms

JT Jones, KA Morelli, EM Vesely, CTS Puerner… - Mbio, 2023‏ - journals.asm.org
People with cystic fibrosis (pwCF) commonly test positive for the pathogenic fungus
Aspergillus fumigatus, which is associated with a decline in lung function. Trikafta is a …

Hybrid histidine kinases in pathogenic fungi

TA Defosse, A Sharma, AK Mondal… - Molecular …, 2015‏ - Wiley Online Library
Histidine kinases (HK) sense and transduce via phosphorylation events many intra‐and
extracellular signals in bacteria, archaea, slime moulds and plants. HK are also widespread …

Regulation of yeast-to-hyphae transition in Yarrowia lipolytica

KR Pomraning, EL Bredeweg, EJ Kerkhoven, K Barry… - MSphere, 2018‏ - journals.asm.org
The yeast Yarrowia lipolytica undergoes a morphological transition from yeast-to-hyphal
growth in response to environmental conditions. A forward genetic screen was used to …

The two-component signal transduction system and its regulation in Candida albicans

B Liao, X Ye, X Chen, Y Zhou, L Cheng, X Zhou, B Ren - Virulence, 2021‏ - Taylor & Francis
Candida albicans, which can cause superficial and life-threatening systemic infections, is
the most common opportunistic fungal pathogen in the human microbiome. The two …