The loss of control over drug intake that occurs in addiction was initially believed to result
from disruption of subcortical reward circuits. However, imaging studies in addictive …

Despite intensive scientific investigation and public health imperatives, drug addiction
treatment outcomes have not significantly improved in more than 50years. Non-invasive …

This chapter begins with a summary of the initial findings on the effects of insula lesions on
smoking behavior as well as more recent human‐lesion studies that replicate and extend …

This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

More than 80% of addicted individuals fail to seek treatment, which might reflect impairments
in recognition of severity of disorder. Considered by some as intentional deception, such …

Abstract Introduction and Aims Cognitive impairments in substance use disorder predict
treatment outcome and are assumed to differ between substances. They often go …

The nature of addiction is often debated along moral versus biological lines. However,
recent advances in neuroscience offer insights that might help bridge the gap between these …

Most substance abusers simultaneously use and abuse more than one substance, even
when there is a clear drug of choice. This pattern creates a great challenge in relating …

Food craving (defined as an intense desire to eat a specific food) is of interest because it is
extremely common and because it influences obesity or nutritional status. It has also been …

The promise of a new generation of therapies targeted to address neurobiological
mechanisms thought to underlie psychological disorders, particularly depression, using …