Microbiota regulation of viral infections through interferon signaling
The interferon (IFN) response is the major early innate immune response against invading
viral pathogens and is even capable of mediating sterilizing antiviral immunity without the …
viral pathogens and is even capable of mediating sterilizing antiviral immunity without the …
Differential roles of interferons in innate responses to mucosal viral infections
Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral
infection and are crucial for control of viral replication and dissemination, especially at …
infection and are crucial for control of viral replication and dissemination, especially at …
IFN-λ derived from nonsusceptible enterocytes acts on tuft cells to limit persistent norovirus
Norovirus is a leading cause of epidemic viral gastroenteritis, with no currently approved
vaccines or antivirals. Murine norovirus (MNoV) is a well-characterized model of norovirus …
vaccines or antivirals. Murine norovirus (MNoV) is a well-characterized model of norovirus …
A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity
Acute gastroenteritis caused by human noroviruses (HuNoVs) is a significant global health
and economic burden and is without licensed vaccines or antiviral drugs. The GII. 4 HuNoV …
and economic burden and is without licensed vaccines or antiviral drugs. The GII. 4 HuNoV …
New insights and enhanced human norovirus cultivation in human intestinal enteroids
K Ettayebi, VR Tenge, NW Cortes-Penfield… - Msphere, 2021 - Am Soc Microbiol
Human noroviruses (HuNoVs) are the leading cause of epidemic and sporadic acute
gastroenteritis worldwide. We previously demonstrated human intestinal stem cell-derived …
gastroenteritis worldwide. We previously demonstrated human intestinal stem cell-derived …
Organoids in gastrointestinal diseases: from experimental models to clinical translation
We are entering an era of medicine where increasingly sophisticated data will be obtained
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …
Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning
SC Lin, K Haga, XL Zeng, MK Estes - Nature protocols, 2022 - nature.com
Human intestinal tissue–derived enteroids (HIEs; also called organoids) are a powerful ex
vivo model for gastrointestinal research. Genetic modification of these nontransformed …
vivo model for gastrointestinal research. Genetic modification of these nontransformed …
CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection
Globally, most cases of gastroenteritis are caused by pandemic GII. 4 human norovirus
(HuNoV) strains with no approved therapies or vaccines available. The cellular pathways …
(HuNoV) strains with no approved therapies or vaccines available. The cellular pathways …
Immunomodulation by enteric viruses
L Bernard-Raichon, K Cadwell - Annual Review of Virology, 2023 - annualreviews.org
Enteric viruses display intricate adaptations to the host mucosal immune system to
successfully reproduce in the gastrointestinal tract and cause maladies ranging from …
successfully reproduce in the gastrointestinal tract and cause maladies ranging from …
Blockade of interferon signaling decreases gut barrier integrity and promotes severe West Nile virus disease
The determinants of severe disease caused by West Nile virus (WNV) and why only~ 1% of
individuals progress to encephalitis remain poorly understood. Here, we use human and …
individuals progress to encephalitis remain poorly understood. Here, we use human and …