Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Introduction K+ channels are of great interest to epilepsy research as mutations in their
genes are found in humans with inherited epilepsy. At the level of cellular physiology, K+ …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related
mortality, but the precise cellular substrates involved remain elusive. Epilepsy-associated …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among
patients with epilepsy, causing a global public health burden. The underlying mechanisms …

Epilepsy is one of the most common neurological disorders in humans. Recently, long
noncoding RNAs (lncRNAs) have been reported to be important players in neurological …

ABSTRACT Voltage-gated Kv1. 1 potassium channel α-subunits are broadly expressed in
the nervous system where they act as critical regulators of neuronal excitability. Mutations in …

Epilepsy is one of the most common neurological disorders, and sudden unexpected death
in epilepsy (SUDEP) is the most severe outcome of refractory epilepsy. Arrhythmia is one of …

The core subunits of the KV7. 2, KV7. 3, and KV7. 5 channels, encoded by the KCNQ2,
KCNQ3, and KCNQ5 genes, are expressed across various cell types and play a key role in …

Sudden unexpected death in epilepsy (SUDEP) is a devastating complication of epilepsy
with possible sex‐specific risk factors, although the exact relationship between sex and …

Kynurenic acid (KYNA, 4-oxoquinoline-2-carboxylic acid), an intermediate of the tryptophan
metabolism, has been recognized to exert different neuroactive actions; however, the need …