The evolution of data-driven modeling in organic chemistry

WL Williams, L Zeng, T Gensch, MS Sigman… - ACS central …, 2021 - ACS Publications
Organic chemistry is replete with complex relationships: for example, how a reactant's
structure relates to the resulting product formed; how reaction conditions relate to yield; how …

Gut microbiota functions: metabolism of nutrients and other food components

I Rowland, G Gibson, A Heinken, K Scott… - European journal of …, 2018 - Springer
The diverse microbial community that inhabits the human gut has an extensive metabolic
repertoire that is distinct from, but complements the activity of mammalian enzymes in the …

Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and …

EA Thévenot, A Roux, Y Xu, E Ezan… - Journal of proteome …, 2015 - ACS Publications
Urine metabolomics is widely used for biomarker research in the fields of medicine and
toxicology. As a consequence, characterization of the variations of the urine metabolome …

Advanced methods of plant disease detection. A review

F Martinelli, R Scalenghe, S Davino, S Panno… - Agronomy for …, 2015 - Springer
Plant diseases are responsible for major economic losses in the agricultural industry
worldwide. Monitoring plant health and detecting pathogen early are essential to reduce …

[PDF][PDF] A Large‐scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma

P Luo, P Yin, R Hua, Y Tan, Z Li, G Qiu, Z Yin… - …, 2018 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of
effective biomarkers for the early detection of HCC results in unsatisfactory curative …

Translational biomarker discovery in clinical metabolomics: an introductory tutorial

J **a, DI Broadhurst, M Wilson, DS Wishart - Metabolomics, 2013 - Springer
Metabolomics is increasingly being applied towards the identification of biomarkers for
disease diagnosis, prognosis and risk prediction. Unfortunately among the many published …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Reflections on univariate and multivariate analysis of metabolomics data

E Saccenti, HCJ Hoefsloot, AK Smilde, JA Westerhuis… - Metabolomics, 2014 - Springer
Metabolomics experiments usually result in a large quantity of data. Univariate and
multivariate analysis techniques are routinely used to extract relevant information from the …

Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: Synthesis, analysis, bioavailability, and bioactivity

P Mena, L Bresciani, N Brindani, IA Ludwig… - Natural Product …, 2019 - pubs.rsc.org
Covering: 1958 to June 2018 Phenyl-γ-valerolactones (PVLs) and their related
phenylvaleric acids (PVAs) are the main metabolites of flavan-3-ols, the major class of …

[HTML][HTML] A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments

AC Dona, M Kyriakides, F Scott, EA Shephard… - Computational and …, 2016 - Elsevier
Metabonomics/metabolomics is an important science for the understanding of biological
systems and the prediction of their behaviour, through the profiling of metabolites. Two …