HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis

J Wang, I Jelcic, L Mühlenbruch, V Haunerdinger… - Cell, 2020 - cell.com
The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …

Autoimmunity in Anti–Glomerular Basement Membrane Disease: A Review of Mechanisms and Prospects for Immunotherapy

H Kuang, J Liu, X Jia, Z Cui, M Zhao - American Journal of Kidney Diseases, 2023 - Elsevier
Anti–glomerular basement membrane (anti-GBM) disease is an organ-specific autoimmune
disorder characterized by autoantibodies against the glomerular and alveolar basement …

Pathogenesis of Pulmonary Manifestations in ANCA-Associated Vasculitis and Goodpasture Syndrome

E Fouka, F Drakopanagiotakis… - International Journal of …, 2024 - mdpi.com
Pulmonary manifestations of vasculitis are associated with significant morbidity and mortality
in affected individuals. They result from a complex interplay between immune dysregulation …

[HTML][HTML] The metalloproteinase ADAMTS5 is expressed by interstitial inflammatory cells in IgA nephropathy and is proteolytically active on the kidney matrix

S Taylor, M Whitfield, J Barratt… - The Journal of …, 2020 - journals.aai.org
Abstract In IgA nephropathy (IgAN), IgA immune complexes are deposited in the mesangium
and drive inflammation and extracellular matrix (ECM) remodelling. The functional links …

[HTML][HTML] Anti-glomerular basement membrane disease in HLA-identical non-twin siblings

PC Fernández, MDS de la Nieta, MA Segura… - Nefrología (English …, 2022 - Elsevier
Anti glomerular basement membrane disease (AGBM) is an autoinmune disorder
characterised by the presence of anti-glomerular basement membrane (Anti-GBM) …

[HTML][HTML] Enfermedad antimembrana basal glomerular en hermanos no gemelos con HLA idéntico

PC Fernández, MDS de la Nieta, MA Segura, LG López… - nefrologia, 2022 - Elsevier
La enfermedad antimembrana basal glomerular (EMBG) es un trastorno autoinmune
caracterizado por la presencia de anticuerpos antimembrana basal glomerular (AMBG) …

Anti-GBM (Goodpasture) disease: Pathogenesis, clinical manifestations, and diagnosis

CD Pusey, M Segelmark, FC Fervenza - UpToDate, 2023 - uptodate.com
Anti-GBM disease is a small vessel vasculitis in which circulating antibodies are directed
against an antigen intrinsic to the glomerular basement membrane (GBM) and alveolar …

肠-肾轴在新月体肾炎发病机制中的研究进展

尹欢欢, 施潇潇, 陈丽萌 - 基础医学与临床, 2022 - journal11.magtechjournal.com
新月体肾炎(CreGN) 是最凶险的肾小球肾炎, 常常导致终末期肾病. 免疫机制是其发病和决定
预后最重要的因素. **年来, 肠道和肠道菌群在包括CreGN 在内的多种肾脏病中作用受到关注 …

Autoimmunity in 2019

C Selmi - Clinical Reviews in Allergy & Immunology, 2020 - Springer
Based on the PubMed data, we have been performing a yearly evaluation of the
publications related to autoimmune diseases and immunology to ascertain the relative …