Real-time fluorescence imaging in intraoperative decision making for cancer surgery

LJ Lauwerends, PBAA van Driel, RJB de Jong… - The Lancet …, 2021 - thelancet.com
Fluorescence-guided surgery is an intraoperative optical imaging method that provides
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …

In-vivo Raman spectroscopy: from basics to applications

E Cordero, I Latka, C Matthäus… - Journal of biomedical …, 2018 - spiedigitallibrary.org
For more than two decades, Raman spectroscopy has found widespread use in biological
and medical applications. The instrumentation and the statistical evaluation procedures …

Intraoperative imaging in pathology-assisted surgery

FJ Voskuil, J Vonk, B van der Vegt, S Kruijff… - Nature biomedical …, 2022 - nature.com
The pathological assessment of surgical specimens during surgery can reduce the
incidence of positive resection margins, which otherwise can result in additional surgeries or …

Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics

IP Santos, EM Barroso, TCB Schut, PJ Caspers… - Analyst, 2017 - pubs.rsc.org
Oncological applications of Raman spectroscopy have been contemplated, pursued, and
developed at academic level for at least 25 years. Published studies aim to detect pre …

Raman spectroscopy: guiding light for the extracellular matrix

MS Bergholt, A Serio, MB Albro - Frontiers in bioengineering and …, 2019 - frontiersin.org
The extracellular matrix (ECM) consists of a complex mesh of proteins, glycoproteins, and
glycosaminoglycans, and is essential for maintaining the integrity and function of biological …

Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

MJ Baker, HJ Byrne, J Chalmers, P Gardner… - Analyst, 2018 - pubs.rsc.org
Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a
detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic …

Advancing Raman spectroscopy from research to clinic: Translational potential and challenges

S Tanwar, SK Paidi, R Prasad, R Pandey… - Spectrochimica Acta Part …, 2021 - Elsevier
Raman spectroscopy has emerged as a non-invasive and versatile diagnostic technique
due to its ability to provide molecule-specific information with ultrahigh sensitivity at near …

Application of vibrational spectroscopy and imaging to point-of-care medicine: a review

S Pahlow, K Weber, J Popp, BR Wood… - Applied …, 2018 - journals.sagepub.com
Vibrational spectroscopy and imaging promise molecular information that can be rapidly
acquired without the need for specialized stains or dyes, thereby potentially simplifying and …

[HTML][HTML] Depth of invasion in early stage oral cavity squamous cell carcinoma: The optimal cut-off value for elective neck dissection

CGF van Lanschot, YP Klazen, MAJ de Ridder, H Mast… - Oral oncology, 2020 - Elsevier
Objectives Depth of invasion (DOI) is the most important predictor for lymph node metastasis
(LNM) in early stage (T1-T2) oral cancer. The aim of this study is to validate the cut-off value …

Surgical margins in oral cavity squamous cell carcinoma: current practices and future directions

JJ Kain, AC Birkeland, N Udayakumar… - The …, 2020 - Wiley Online Library
Objective To discuss the current available techniques for intraoperative margin assessment
in the surgical treatment of oral squamous cell carcinoma (OSCC) through a review of the …