Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration

MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …

Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

[HTML][HTML] Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature

Y Shimizu, EH Ntege, H Sunami, Y Inoue - Regenerative therapy, 2022 - Elsevier
Hair loss, or alopecia, is associated with several psychosocial and medical comorbidities,
and it remains an economic burden to individuals and the society. Alopecia is attributable to …

A comparative analysis of multipotent mesenchymal stromal cells derived from different sources, with a focus on neuroregenerative potential

Y Petrenko, I Vackova, K Kekulova, M Chudickova… - Scientific reports, 2020 - nature.com
Multipotent mesenchymal stromal cells (MSCs) can be considered an accessible therapeutic
tool for regenerative medicine. Here, we compared the growth kinetics, immunophenotypic …

[HTML][HTML] Manufacturing of human extracellular vesicle-based therapeutics for clinical use

M Gimona, K Pachler, S Laner-Plamberger… - International journal of …, 2017 - mdpi.com
Extracellular vesicles (EVs) derived from stem and progenitor cells may have therapeutic
effects comparable to their parental cells and are considered promising agents for the …

Stem cell-derived exosomes: a new strategy of neurodegenerative disease treatment

N Fayazi, M Sheykhhasan, S Soleimani Asl… - Molecular …, 2021 - Springer
Short-term symptomatic treatment and dose-dependent side effects of pharmacological
treatment for neurodegenerative diseases have forced the medical community to seek an …

FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation …

Y Geng, X Long, Y Zhang, Y Wang, G You… - Journal of Translational …, 2023 - Springer
Background Parkinson's disease (PD), characterized by the progressive loss of
dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens …

[HTML][HTML] Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access

L Giovannelli, E Bari, C Jommi, F Tartara, D Armocida… - Bioactive Materials, 2023 - Elsevier
Neurodegenerative diseases represent a growing burden on healthcare systems worldwide.
Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their …

Dental pulp stem cell-derived secretome and its regenerative potential

JK Bar, A Lis-Nawara, PG Grelewski - International journal of molecular …, 2021 - mdpi.com
The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of
various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo …

Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine

TNA Gunawardena, MT Rahman… - Journal of tissue …, 2019 - Wiley Online Library
Recent studies suggest that the main driving force behind the therapeutic activity observed
in mesenchymal stem cells (MSCs) are the paracrine factors secreted by these cells. These …