Low levels of human medicines (pharmaceuticals) have been detected in many countries in
sewage treatment plant (STP) effluents, surface waters, seawaters, groundwater and some …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

▪ Abstract The peroxisome proliferator-activated receptors (PPARs) are a group of three
nuclear receptor isoforms, PPARγ, PPARα, and PPARδ, encoded by different genes. PPARs …

B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

Every 5 years, the JAS publishes guidelines for the treatment of dyslipidemia and
atherosclerosis. To date, this society has released four such guidelines. Since 2007, the JAS …

Treatment with fibrates, a widely used class of lipid-modifying agents, results in a substantial
decrease in plasma triglycerides and is usually associated with a moderate decrease in LDL …

Prolonged deprivation of food induces dramatic changes in mammalian metabolism,
including the release of large amounts of fatty acids from the adipose tissue, followed by …

Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …

We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of
molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation …

Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory
and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of …