Radial glia-like neural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus
give rise to dentate granule cells (DGCs) and astrocytes throughout life, a process referred …

Delivering genes to and across the brain vasculature efficiently and specifically across
species remains a critical challenge for addressing neurological diseases. We have evolved …

Adaptive neuroplasticity is a pivotal mechanism for healthy brain development and
maintenance, as well as its restoration in disease-and age-associated decline. Management …

SPARC (secreted protein acidic and rich in cysteine) family of proteins is a class of protein
involved in tissue development and repair by regulating cell adhesion, proliferation …

Hevin is secreted by astrocytes and its synaptogenic effects are antagonized by the related
protein, SPARC. Hevin stabilizes neurexin-neuroligin transsynaptic bridges in vivo. A third …

Astrocytic-secreted matricellular proteins have been shown to influence various aspects of
synaptic function. More recently, they have been found altered in animal models of …

The rodent visual thalamus has served as a powerful model to elucidate the cellular and
molecular mechanisms that underlie sensory circuit formation and function. Despite …

Alzheimer's disease is a progressive neurodegenerative disorder affecting a substantial
portion of the older population, with the number of afflicted individuals expected to grow with …

Abstract Analysis of long‐term potentiation (LTP) provides a powerful window into cellular
mechanisms of learning and memory. Prior work shows late LTP (L‐LTP), lasting> 3 hr …

Background Secreted protein acidic and rich in cysteine-like 1 (SPARCL1) regulates
synaptic stability and is up-regulated during axonal regeneration. Here, serum SPARCL1 …